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IgA Production Requires B Cell Interaction with Subepithelial Dendritic Cells in Peyer’s Patches

Monday, August 29, 2016  
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Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG.

 

Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer’s patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of PPs. There, B cells... read more